Some publications still used the synonym, hedyotis corymbosa, instead of the accepted botanical name oldenlandia corymbosa. Widely differing treatments have long been used in different regions and floras. Distribution of asperuloside and scandosidmethylesther in leaf, stem, fruit and root of hedyotis corymbosa l. A new species and a synopsis of the hedyotisoldenlandia. Pdf chemical constituents from oldenlandia corymbosa l. List of various diseases cured by hedyotis herbacea. Published under licence by iop publishing ltd iop conference series. Pdf hedyotis corymbosa was subjected to anatomical and micromorphological studies in order to locate and identify important biomarkers for correct. Morphology of plant the grasses grow scattered shade, little weak, height 15 50 cm, grow fertile in the moist soil on the side of the road, roadside ditch, have many branch. Names of hedyotis herbacea in various languages of the world are also given. Br squr which are proven to have cytotoxic effect to cancer cells. Yields and content of ursolic acid in pearl grass hedyotis corymbosa when utilizing cow manure fertilizer in different shades.
Cytotoxicity assay from fractions of hedyotis corymbosa. Comparative chemical composition of the essential oils from hedyotis diffusa willd and hedyotis corymbosa lam by gcms wu jian, yang tairan, xu ying, zhang yi and xiang zheng introduction. Rubiaceae is a weedy annual herb, found throughout india. Isolation of an anticancer asperuloside from hedyotis corymbosa l.
Previously, hedyotis corymbosa ethanolic extract hee which contain ursolic acid reported to inhibit crc growth via induction of cancer cell apoptosis and blocked the cell cycle, preventing g1 to s progression where cyclin d highly espressed in this phase. Plants profile for oldenlandia corymbosa flattop mille graines. List of various diseases cured by hedyotis diffusa. Yields and content of ursolic acid in pearl grass hedyotis. Rubiaceae is an important folk herb used to prevent and cure hepatitis and liver cancer in taiwan. Ethanolic extract of hedyotis corymbosa and its combination. In the present study, the hepatoprotective effect of the methanolic extract of the whole plant of hedyotis corymbosa against paracetamol overdoseinduced liver damage in wistar rats was studied. Hedyotis starviolet is a genus of flowering plants in the family rubiaceae. Malaulasimanaso oldenlandia corymbosa flat top mile. Pertumbuhan dan struktur anatomi rumput mutiara hedyotis. Hedyotis corymbosa is herb plant that used by chinese people for a long time ago. Hedyotis corymbosa linn is spreading, suffruticose annual, belongs to family rubiaceae frequently met with in field through out india, usually during rainy season. Both the extract showed significant decrease in ulcer compared to control group. Digital chinese med icine 1 2018 302309 establishing a quality control system of hedyotis corymbosa.
The chinese name for oldenlandia corymbosa is shui xian cao. L d jayanti 1, a yunus 2, b pujiasmanto 2 and y widyastuti 3. Hedyotis corymbosa has shown significant antiulcer activity against aspirin in rats. Pdf from the whole plants of oldenlandia corymbosa of thai origin, ten. It was initially recorded in the illustrated catalogue of plants, a chinese botanical drug monograph. Pdf establishing a quality control system of hedyotis corymbosa. In vitro antioxidant activity of hedyotis corymbosa l. Br squr, provides high potency to be developed as novel breast cancer chemopreventive agents. The oils were collected, dried over anhydrous sodium sulphate and stored at 4. Uses, benefits, cures, side effects, nutrients in hedyotis diffusa. It was found that the optimum extraction conditions were 3% of enzyme concentration x 1, 30 of liquidtosolid ratio x 2, 56c of extraction temperature x 3, 200w of ultrasonic power x 4, 10 min of.
Hedyotis diffusa combined with scutellaria barbata are the. Hedyotis corymbosa is one of the most popular species, which is regarded as the active ingredients in several chinese herbal medicines 2, 3. Objective hedyotis corymbosa shui xian cao, hc is the main antitumor medicine in china and other southeast. The situation is far from resolution or even general consensus and so many authors treat the genus very broadly. Hedyotis corymbosa is used in traditional medicine of india and china. Hc is also indiscriminately sold as hd in the wholesale chain and food markets. Rumput mutiara dengan nama latin hedyotis corymbosa adalah salah satu tumbuhan obat yang digunakan oleh penduduk indonesia secara. All structured data from the file and property namespaces is available under the creative commons cc0 license. Molecules free fulltext discovery of the potential. The type species for the genus is hedyotis fruticosa.
Herbal extracts of andrographis paniculata ap and hedyotis corymbosa hc are known as hepatoprotective and feverreducing drugs since ancient time and they have been used regularly by the people in the south asian subcontinent. In this study, optimization of enzymeassisted extraction, purification, characterization, and its bioactivities of polysaccharides from hedyotis corymbosa hcp was investigated. Hedyotis is native to tropical and subtropical asia and to islands of the northwest pacific. In the traditional medicine, over 20 hedyotis species have been used for treatment of diseases and healing practices. Antimalarial activities of andrographis paniculata and. Pictures of the plant shown in some website peddling its medicinal value can be quite confusing between these 2 species. Hedyotis is a very problematic genus or group of genera. Article pdf available december 2018 with 11 reads how we measure reads a read is counted each time.
Baihuasheshecao is an ingredient of herbal commonly consumed in china for cancer treatment and health maintenance. If you would like more information about how to print, save, and work with pdfs, highwire press provides a helpful frequently asked questions about pdfs. This page was last edited on 15 january 2017, at 10. Its plant have a lot of benefits for the healing of various diseases such as cancer, diuretic, fever inflammatories, circulatory circulators, detoxification, and indigestion soemardji et al. Hedyotis corymbosa information from itis the integrated taxonomic information system itis provides authoritative taxonomic information on hedyotis corymbosa, as well as other plants, animals, fungi, and microbes of north america and the world.
Distribution of asperuloside, scandosidmethylester in plant. Methanolic extracts of these two plants were tested in vitro on choloroquine sensitive mrcpf20 and resistant mrcpf303 strains of plasmodium falciparum for. How hedyotis herbacea is effective for various diseases is listed in repertory format. The methanolic extract of the plant produced significant hepatoprotective effects as evidenced. Oldenlandia coymbosa, a flowering plant figure 1,2 in the family rubiaceae. Taxonomic and nomenclatural notes on the hedyotis corymbosa.
Pdf taxonomic and nomenclatural notes on the hedyotis. Uses, benefits, cures, side effects, nutrients in hedyotis herbacea. Stemsided, leaves face cross, leaves base short almost sitting, the length of the leave 2 5 cm, pointed tip. Hedyotis corymbosa is used in traditional medicine of india and china to treat various hepatic disorders.
Mcf7 cell line characterized by p53 wildtype is one of the breast cancer cell lines which is res i ta nc odx ub v expression of pgp and bcl2 mealey et al. Names of hedyotis diffusa in various languages of the world are also given. Ursolic acid is a compound found in hedyotis corymbosa l. Earth and environmental science, volume 142, conference 1. This plant is used for their medicinal properties as a folk medicine to treat jaundice, mouth wash in toothache. Neuroprotective constituents from hedyotis diffusa journal.
Dec 29, 2000 kinetic studies for ultrasoundassisted supercritical carbon dioxide extraction of triterpenic acids from healthy tea ingredient hedyotis diffusa and hedyotis corymbosa. Download this pdf file the pdf file you selected should load here if your web browser has a pdf reader plugin installed for example, a recent version of adobe acrobat reader. Istiqomahi, anita rahayu and mudyantini, widya and anggarwulan, endang 2010 pertumbuhan dan struktur anatomi rumput mutiara hedyotis corymbosa l. Discovery of the potential biomarkers for discrimination between. The powders of hedyotis diffusa willd 20g and hedyotis corymbosa lam 20g hydrodistilled separately using a clevenger type apparatus for 4 h. Datura ferox, dubai, oldenlandia corymbosa, ras al khaimah, rubiaceae, solanaceae, united. Kinetic studies for ultrasoundassisted supercritical carbon dioxide extraction of triterpenic acids from healthy tea ingredient hedyotis diffusa and hedyotis corymbosa. Oldenlandia corymbo journal of international academic. Clarification of the phenotypic characteristics and anti. Datura ferox and oldenlandia corymbosa semantic scholar. Establishing a quality control system of hedyotis corymbosa. Hedyotis diffusa induces apoptosis in human breast cancer cells and also inhibits tumor angiogenesis 2628. Tumor inhibition by several components extracted from hedyotis corymbosa and hedyotis diffusa h y hsu phd cancer detection and prevention 1998.
Hcol contains ursolic acid that is known to have anticancer activities with the mechanism of antiproliferative action and antiangiogenesis. Hedyotis corymbosa shui xian cao, hc is the dried whole plant from the genus hedyotis belonging to the family rubiaceae. Hedyotis corymbosa is taken for treating arthralgia, tumor, fever, and jaundice 46. Comparative chemical composition of the essential oils from. Files are available under licenses specified on their description page. Hc, two closely related species of the same genus, are both used for health benefits and disease prevention in china.
Oldenlandia corymbosa name synonyms gerontogea corymbosa l. The pearl grass hedyotis corymbosa is an herbaceous plant that almost all of. Neither the overall identity and limits of this lineage, nor the evolutionary patterns within it, are at all understood or delineated. The alcoholic and the aqueous extract were administered in two doses 200 mgkg and 400 mgkg by oral route 45 minutes prior to the administration of aspirin. Sitosterol and the triterpene acids, oleanolic acid and ursolic acid, have been shown to be present in the indian medicinal plant oldenlandia corymbosa linn. A study of hepatoprotective activity of hedyotis corymbosa. Hedyotis corymbosa is an annual herb that grows in open, moist and. The standard drug lansoprazole 8 mg kg was used for the comparison. The details of some hedyotis species with their traditional uses and reported pharmacological actions are given in table 1. Hedyotis diffusa herb uses, benefits, cures, side effects. Hedyotis herbacea herb uses, benefits, cures, side effects.
Here, these species are circumscribed generally, though not completely, following sivarajan and biju loc. Many species of this genus such as hedyotis biflora, h. This confusion has led to a growing concern about their identification and quality evaluation. Note on the constituents of the indian medicinal plant oldenlandia. How hedyotis diffusa is effective for various diseases is listed in repertory format. The aim of this research is to know the distribution profile of asperuloside, scandosidmethylesther, at the leaf, stem, fruit, and root of hedyotis corymbosa l. In addition, scutellaria barbata is a candidate oral drug that has shown excellent efficacy and safety in early phase clinical trials targeting advanced breast cancer 29. Separation and purification technology 2015, 142, 316325.
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